Why the world’s new currencies will be encrypted The digital revolution has left no stone unturned, but perhaps one of the most unexpected revolutions currently in motion is impacting the financial sector with the arrival of the bitcoin and other decentralized electronic currencies. In September 2017, the The Hiroshi Fujiwara Cyber Security Research Center at Technion hosted the conference: “Decentralized Cryptographic Currencies and Blockchains.” The conference featured some of the elusive movers and shakers in the field of Crypto currencies – including Vitalik Buterin, founder of Ethereum, an open-source platform based on blockchains. Ethereum skyrocketed in 2017, reaching an all-time high. “The first generation of the digital revolution brought us the Internet of information. The second generation — powered by blockchain technology — is bringing us the Internet of value: a new platform to reshape the world of business and transform the old order of human affairs for the better.”– Don Tapscott, Blockchain expert The conference also addressed blockchains, the technological concept behind cryptocurrencies such as Bitcoin, Ethereum, and Zcash; the regulation of virtual currencies; and more. It was attended by students, researchers, and industry professionals. The conference was organized by Prof. Eli Biham, head of the Fujiwara Cyber Security Research Center, and Prof. Eli Ben-Sasson, both from the Faculty of Computer Science. The Hiroshi Fujiwara Cyber Security Research Center at Technion focuses on cyber security research such as software and hardware protection, operating systems and cloud information protection as well as communication to and from the cloud, protection of IoT (Internet of Things) systems, verification of software and hardware, computer vision, security of autonomous systems, machine learning for security, cryptology and cryptanalysis, security and privacy of medical and aeronautical systems.
Science
The Power Behind Power
Innovation aside, the whole entity of civilization depends on energy. Where energy supplies deplete, nations implode, wars explode and suffering corrodes. With a finite supply of fossil fuels and an exponential increase in demand for energy, the Grand Technion Energy Program (GTEP) is presently completing a decade of intense multidisciplinary activity. In these ten years, GTEP has grown from proof of concept to a veritable virtual and physical global hive of energy innovation. Spanning faculties, universities and continents, GTEP’s network of scientists and facilities also has deep inroads into industry, pioneering, for example, the cultivation of expertise to harvest Israel’s newly found natural gas reserves. The GTEP Graduate Studies Program attracts highly motivated graduates in science and engineering who are also required to carry out a research project. The program is designed to produce leaders in all energy-related fields. GTEP is active in four dimensions: Alternative Fuels, Energy Storage and Conversion, Renewable Energy Sources, and Energy Conservation.
Natural Genius
How mimetics at the nano scale are improving man made materials We’re all familiar with the Biblical saying: “There’s nothing new under the sun.” The study of the ancient mechanisms of the brittle starfish led Technion scientists to the innovative secrets which would allow them to follow suit – creating ultra-tough ceramics. An international research team led by Prof. Boaz Pokroy, Dr. Iryna Polishchuk, Dr. Alex Katsman Stas Kozachevich, and Yael Etinger-Geller at the Faculty of Materials Science and Engineering uncovered the unique protective mechanism of highly resistant lenses found in the Ophiocoma wendtii, a coral reef-dwelling brittle starfish. On the arms of this creature are hundreds of focal lenses that hold clues to making tough ceramics. Made of chalk, the lenses are powerful and accurate, and the deciphering of their crystalline and nanoscale structure has occupied lead researcher Prof. Boaz Pokroy and his team for over three years. “Ophiocoma wendtii lenses are created in the open sea, not in a laboratory, and in effect we have discovered a strategy for making brittle material much more tough and durable under natural conditions,” said Pokroy. “It is ‘crystal engineering’ and tempering without heating and quenching – a process that could be very useful in materials science and engineering. Just as nature exhibits creativity in improving an organism’s abilities in various contexts such as strength, sensing, and self-defense, we see very high efficiency by the brittle star’s use of existing raw materials under natural conditions to create hardy and precise transparent lenses,” said Prof. Pokroy. Scientists and engineers can now apply this biostrategy in toughening and strengthening synthetic ceramic materials utilized in various applications that span from optical lenses to automotive turbochargers and even biomaterial implants. The research was published in Science in December 2017.
Predicting Health
For two days in December, researchers and students converged on Technion to hear from the world’s foremost experts on one of the most dynamic and groundbreaking fields today: using deep learning and big data to improve healthcare. Technion recently hosted the first ever “Biomedical Informatics – Big Data Science” Conference, drawing a large audience eager to hear about the latest developments in this fascinating field. Applying deep learning to medical data makes it possible to generate new hypotheses and to make discoveries that would not have been possible in the past. The conference was brilliantly organized by Prof. Roy Kishony, world authority on antibiotic resistance and Head of the Technion Lokey Center for Life Sciences and Engineering and Dr. Kira Radinsky, visiting Technion professor and director of data science of eBay. Their unique synergy resulted in a precise mix of speakers who covered a wide range of topics – from practical applications of data science in medical care to ethical precision medicine and next generation healthcare. In the course of two days, 24 eminent speakers from around the world shared their latest research findings with the international audience. The conference was sponsored by Yad Hanadiv. “We’re living in a fascinating era for scientific research, an era where extensive data is used to improve diagnoses and treatments” – President Prof. Peretz Lavie Prof. Shai Shen-Orr, of the Rappaport Faculty of Medicine and the conference organizing team, addressed the ongoing efforts to build a cell-centered view of genomic data that can be integrated with primary immunology literature. Experts from around the world included Prof. Nigam Shah from Stanford University, who described the initiative he leads, which takes data from electronic health records and uses machine learning to help doctors answer clinical questions. Dr. Hannah Bayer, a neuroscientist from New York University, spoke about the HUMAN Project, which studies 10,000 New York City residents over a period of 20 years, tracking everything from financial and social data to environmental and health factors.
Science shrinks the world
Does evolution depend on competition or collaboration? The discovery of antibiotics saved millions of lives, yet presently world health is in avicious spiral in which bacteria rapidly evolve to defeat available classes of antibiotics. Recruiting resources and knowhow from across the globe, Prof. Roy Kishony and colleagues are returning to the genius of nature to create superdrugs for superbugs. In a creative stroke inspired by the digital billboard for the Hollywood movie, Contagion, Kishony and his team at Technion and Harvard Medical School opened a global window to observe how bacteria evolve as they become impervious to drugs. Described in the September issue of Science, the large-scale experimental tool offered a first glimpse at bacteria adapting to increasingly higher doses of antibiotics, visible to the naked eye. A two-by-four foot petri dish was filled with 14 liters of agar, a seaweed-derived jelly-like substance commonly used in labs to nourish organisms as they grow. The dish was divided into sections saturated with incremental doses of antibiotics. Over the course of two weeks, a camera mounted on the ceiling above the dish took periodic snapshots. The result was a direct and detailed observation of bacterial movement, death and survival: evolution at work. The headline-grabbing Microbial Evolution and Growth Arena, was called the MEGA Plate for short. The video produced by the Kishony lab was viewed over 24 million times, likely making it the most viewed scientific experiment video of all times. According to Kishony, “Seeing bacteria spread for the first time was a thrill. Our MEGA-plate takes complex and often obscure concepts in evolution, such as mutations-selection, lineages, parallel evolution and clonal interference, and provides a visual seeing-is-believing demonstration. It is also a powerful illustration of how easy it is for bacteria to become resistant to antibiotics.” Co-investigators Michael Baym and Tami Lieberman said the images spark the curiosity of lay and professional viewers alike. Ultimately, in a dramatic demonstration of evolved drug resistance, bacteria spread to the highest drug concentration. In the span of 10 days, bacteria produced mutant strains capable of surviving a dose of the antibiotic trimethoprim 1,000 times higher than the one that killed their progenitors. When researchers used another antibiotic (ciprofloxacin) bacteria developed 100,000-fold resistance to the initial dose. Kishony’s lab is collaborating with Israel’s health services and with the Faculty of Computer Science to collate big data in order to develop “predictive genome-based” diagnostics capable of foreseeing bacterial evolution and provide the best treatment at the individual patient level. Roy Kishony is the Marilyn and Henry Taub Professor of Life Sciences and Head of the Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering.
“We must learn from Technion and Israel as to what innovative thinking is”
BBiological pacemakers derived from stem cells could the cardiac revolution that makes electronic devices surgically inserted into the body a thing of the past. When the heart needs support keeping rhythm, the life-saving solution today is the surgical implantation of an electrical pacemaker. While conventional pacemakers have saved many lives, they have always carried surgical risks and come with no hormonal sensitivity and a predetermined battery life. With children’s hearts that are still growing, the pacemaker implant becomes still more limited in its ability to support, as the heart rapidly outgrows it. What could be more natural than to turn to the wisdom of the body itself, and its own biological mechanism for maintaining the heart rhythm?” The sinotrial (SA) node is the natural pacemaker of the heart, and is comprised of a group of dedicated heart cells – SA node pacemaker cells – responsible for initiation of the electrical signal leading to the heart’s rhythmic contraction. The team from the Technion, Rambam Health Care Campus, and the University Health Network’s McEwen Centre for Regenerative Medicine in Toronto, employed developmental biology to develop a differentiation protocol for the creation of pacemaker cells from human embryonic stem cells. “The pacemaker generated from embryonic stem cells exhibits the molecular, electrical and functional properties characteristic of human pacemaker cells and is able to pace the heart in animal models of abnormally slow heart rate,” said Prof. Gepstein. “It is an effective and promising alternative to natural pacemaker cells in the event of their dysfunction. This development is significant both in terms of research – because it will enable scientists to study the heart in new ways, and in practical terms – since we are presenting an ‘assembly line’ here for an unlimited reservoir of pacemaker cells to treat patients with heart rhythm problems. Together with our Canadian partners, we present a method for producing a population of pure pacemaker cells, and provide proof that they work well as a substitute for natural pacemaker cells that have been damaged.” Prof. Lior Gepstein holds the Sohnis Chair in Tissue Engineering and Regenerative Medicine.

